Systemic lupus erythematosus
Identifieur interne : 002259 ( Main/Exploration ); précédent : 002258; suivant : 002260Systemic lupus erythematosus
Auteurs : Guillermo Ruiz-Irastorza [Royaume-Uni] ; Munther A. Khamashta [Royaume-Uni] ; Gabriella Castellino [Royaume-Uni] ; Graham Rv Hughes [Royaume-Uni]Source :
- The Lancet [ 0140-6736 ] ; 2001.
English descriptors
- Teeft :
- American college, Anticardiolipin antibodies, Anticoagulation, Antiphospholipid, Antiphospholipid antibodies, Antiphospholipid syndrome, Arterial thrombosis, Arthritis, Arthritis rheum, Clin, Cyclophosphamide, Erythematosus, Heparin, Immunoglobulin, Intravenous, Intravenous immunoglobulin, Khamashta, Lancet, Lancet publishing group, Lupus, Lupus anticoagulant, Lupus erythematosus, Lupus nephritis, Methotrexate, Mofetil, Mortality studies, Mycophenolate, Mycophenolate mofetil, Nephritis, Obstet gynecol, Oral anticoagulation, Pilot study, Placebo, Pregnancy, Previous thrombosis, Proliferative, Proliferative lupus nephritis, Randomised, Randomized, Recurrence, Recurrent miscarriage, Rheum, Rheumatol, Single center, Syndrome, Systemic, Systemic lupus erythematosus, Thalidomide, Thrombosis, Transplantation, Venous, Venous thromboembolism.
Abstract
Summary: This review covers major advances in clinical issues related to systemic lupus erythematosus (SLE) published between 1995 and 2000. The classification criteria for both SLE and antiphospholipid syndrome (APS) have been updated, and up to 19 different subsets of neuropsychiatric lupus have been defined. New epidemiological data show that the incidence of new cases and the survival of patients with SLE are both increasing. Several randomised controlled trials have defined the role of cyclophosphamide, methotrexate, antimalarials, and hormonal treatment in the management of SLE. New data are available for drugs such as ciclosporin and thalidomide. Finally, several new treatments for severe refractory cases, such as mycophenolate mofetil and stem-cell transplantation, are being increasingly used. New data also refer to management of thrombosis in APS and high-risk pregnancies in women with SLE or APS.
Url:
DOI: 10.1016/S0140-6736(00)04239-2
Affiliations:
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Khamashta</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author><author><name sortKey="Castellino, Gabriella" sort="Castellino, Gabriella" uniqKey="Castellino G" first="Gabriella" last="Castellino">Gabriella Castellino</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author><author><name sortKey="Hughes, Graham Rv" sort="Hughes, Graham Rv" uniqKey="Hughes G" first="Graham Rv" last="Hughes">Graham Rv Hughes</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="ISSN">0140-6736</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">357</biblScope><biblScope unit="issue">9261</biblScope><biblScope unit="page" from="1027">1027</biblScope><biblScope unit="page" to="1032">1032</biblScope></imprint><idno type="ISSN">0140-6736</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>American college</term><term>Anticardiolipin antibodies</term><term>Anticoagulation</term><term>Antiphospholipid</term><term>Antiphospholipid antibodies</term><term>Antiphospholipid syndrome</term><term>Arterial thrombosis</term><term>Arthritis</term><term>Arthritis rheum</term><term>Clin</term><term>Cyclophosphamide</term><term>Erythematosus</term><term>Heparin</term><term>Immunoglobulin</term><term>Intravenous</term><term>Intravenous immunoglobulin</term><term>Khamashta</term><term>Lancet</term><term>Lancet publishing group</term><term>Lupus</term><term>Lupus anticoagulant</term><term>Lupus erythematosus</term><term>Lupus nephritis</term><term>Methotrexate</term><term>Mofetil</term><term>Mortality studies</term><term>Mycophenolate</term><term>Mycophenolate mofetil</term><term>Nephritis</term><term>Obstet gynecol</term><term>Oral anticoagulation</term><term>Pilot study</term><term>Placebo</term><term>Pregnancy</term><term>Previous thrombosis</term><term>Proliferative</term><term>Proliferative lupus nephritis</term><term>Randomised</term><term>Randomized</term><term>Recurrence</term><term>Recurrent miscarriage</term><term>Rheum</term><term>Rheumatol</term><term>Single center</term><term>Syndrome</term><term>Systemic</term><term>Systemic lupus erythematosus</term><term>Thalidomide</term><term>Thrombosis</term><term>Transplantation</term><term>Venous</term><term>Venous thromboembolism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Summary: This review covers major advances in clinical issues related to systemic lupus erythematosus (SLE) published between 1995 and 2000. The classification criteria for both SLE and antiphospholipid syndrome (APS) have been updated, and up to 19 different subsets of neuropsychiatric lupus have been defined. New epidemiological data show that the incidence of new cases and the survival of patients with SLE are both increasing. Several randomised controlled trials have defined the role of cyclophosphamide, methotrexate, antimalarials, and hormonal treatment in the management of SLE. New data are available for drugs such as ciclosporin and thalidomide. Finally, several new treatments for severe refractory cases, such as mycophenolate mofetil and stem-cell transplantation, are being increasingly used. New data also refer to management of thrombosis in APS and high-risk pregnancies in women with SLE or APS.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Ruiz Irastorza, Guillermo" sort="Ruiz Irastorza, Guillermo" uniqKey="Ruiz Irastorza G" first="Guillermo" last="Ruiz-Irastorza">Guillermo Ruiz-Irastorza</name></noRegion><name sortKey="Castellino, Gabriella" sort="Castellino, Gabriella" uniqKey="Castellino G" first="Gabriella" last="Castellino">Gabriella Castellino</name><name sortKey="Hughes, Graham Rv" sort="Hughes, Graham Rv" uniqKey="Hughes G" first="Graham Rv" last="Hughes">Graham Rv Hughes</name><name sortKey="Khamashta, Munther A" sort="Khamashta, Munther A" uniqKey="Khamashta M" first="Munther A" last="Khamashta">Munther A. Khamashta</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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